Pediatric METABOLIC SYNDROME Roya Kelishadi

Roya Kelishadi, MD

Professor of Pediatrics

Child Growth and Development Research Center,

Research Institute for Primordial Prevention of

Non-communicable Disease,

Isfahan University of Medical Sciences

Dec 2019

Obesity Trajectory

• Phase I – Steady increase in childhood obesity
• Phase II – Emergence of serious obesity related comorbidities
• Phase III – Medical complications lead to life threatening disease and death in middle age
• Phase IV – Acceleration of obesity epidemic by transgenerational transmission

Ludwig DS. Childhood obesity—the shape of things to come. N Engl J Med. 2007;357(23):2325-2327.

Childhood Obesity

• Epidemic – Widespread in population (adults and children)
• Progressive – Childhood obesity becomes adult obesity
• Alters Development – Physically, emotionally, psychosocially
• Chronic disease – Lifelong morbidity accelerates “adult” disease into childhood
• Increases morbidity/mortality – First generation to have shorter lifespan than parents